Basic Information
VIS ID
TVIS10008549
Fusion event
HBV-LOC112268142 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr15
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
78973977/78681635 (Hg38)
End
78973977/78681635 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC112268142
Nearest miRNA
hsa-mir-10393/Upstream/2919320; hsa-mir-11181/Downstream/528153;
Nearest TSS
ENST00000557528/Upstream/21103; ENST00000559697/Downstream/26417;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/40156, chr15-CpG: 17/Downstream/69447
Nearby gene
CHRNB4(-40390) ; LOC646938(+70402) ;
Upstream sequence
TCAAAGCTTGCTTCCATCCCAGTGACCTATATGTCTGAATATAAATGTTTCTTTGAGCCATCCTTCTGCCCCACCACAGCAGTGAGGCCACAGGAGAGAG
Downstream sequence
GGAAGACATTTAGGAAGAGATGAGTTCATAGAGGGGAGGGAGAGATGAGGGAGCTCTCAGAGGCCATCTGGATAGTGTACTTCCCATTCCCCCATGGGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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