Basic Information
VIS ID
TVIS10008550
Fusion event
HBV-LOC112268142 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2653
Orient
-
Integrated sequence
ACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTT| |TATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTAC
Host Sequence
Chromosome
chr15
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
78974007/78681665 (Hg38)
End
78974007/78681665 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC112268142
Nearest miRNA
hsa-mir-10393/Upstream/2919350; hsa-mir-11181/Downstream/528123;
Nearest TSS
ENST00000557528/Upstream/21133; ENST00000559697/Downstream/26387;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/40186, chr15-CpG: 17/Downstream/69417
Nearby gene
CHRNB4(-40420) ; LOC646938(+70372) ;
Upstream sequence
ATGTCTGAATATAAATGTTTCTTTGAGCCATCCTTCTGCCCCACCACAGCAGTGAGGCCACAGGAGAGAGGGAAGACATTTAGGAAGAGATGAGTTCATA
Downstream sequence
GAGGGGAGGGAGAGATGAGGGAGCTCTCAGAGGCCATCTGGATAGTGTACTTCCCATTCCCCCATGGGGACACGTGTATGGCCCCCTTCCTAATTACTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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