Basic Information
VIS ID
TVIS10008556
Fusion event
HBV-LOC105374536 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2672
Orient
+
Integrated sequence
ATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAAT| |ATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGG
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
25429866/25428244 (Hg38)
End
25429866/25428244 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC105374536
Nearest miRNA
hsa-mir-12113/Upstream/907954; hsa-mir-1243/Downstream/3391338;
Nearest TSS
ENST00000502981/Upstream/13092; ENST00000515188/Downstream/180467;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/50591, chr4-CpG: 132/Downstream/76715
Nearby gene
ANAPC4(-9746) ; SLC34A2(+227569) ;
Upstream sequence
ggttggggttggggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttgggttagggttggggttggggttg
Downstream sequence
GCAAAGCACAGGCTTCCTGGCTGAGTCTGGGGGTTGCCGGGCATTACTCCGCCAGACCCAGTGGTACGGGTCTGGGCGTGGATCTAGGAAGGTGTACATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate