Basic Information
VIS ID
TVIS10008564
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1552
Orient
+
Integrated sequence
CGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCC| |GTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCT
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
29295366/29295259 (Hg38)
End
29295366/29295259 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/12139267; hsa-mir-103a-1/Downstream/2640843;
Nearest TSS
ENST00000502646/Upstream/103560; ENST00000506396/Downstream/94681;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/366729, chr5-CpG: 37/Downstream/1898586
Nearby gene
LSP1P3(-367946) ; CDH6(+1898396) ;
Upstream sequence
TAGAAAGAGATTTCCAGAGCCCATGGTGTGCTTTTTTCTTAGTGATTTGTAACTTTAATTTTTAACTGACTAAAATGTTATAATTTAACCTAAAATGTTG
Downstream sequence
ttcccagaggtgattctaactcacttggtgattatttttcagaggaatggctcccaggttctgaagaaaagcagccttggcttgtaaagcaagaaagcaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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