Basic Information
VIS ID
TVIS10008565
Fusion event
HBV-LOC105374724 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1751
Orient
-
Integrated sequence
TTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGG| |AGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGT
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
35836009/35835907 (Hg38)
End
35836009/35835907 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
LOC105374724
Nearest miRNA
hsa-mir-10397/Upstream/3441432; hsa-mir-103a-1/Downstream/311985;
Nearest TSS
ENST00000502646/Upstream/8889; ENST00000515665/Downstream/16788;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/217670, chr5-CpG: 85/Downstream/315488
Nearby gene
SPEF2(-21296) ; IL7R(+20968) ;
Upstream sequence
actccatcttgcttctagccacacacgctggctgccttcactcattcctggatgtaggctaagctaataatgggaggaaatttagtttatagtttaactt
Downstream sequence
AAACATTTCTTGTAATTGCAAAACATCTACCTAGAAAGTTGAGGGAAAGGAGTGGTGGCAATGGTTTCTTTTTTCAGTGTTAATCAGAGAAAGACTGAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate