Basic Information
VIS ID
TVIS10008566
Fusion event
HBV-LOC105374724 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
157
Orient
-
Integrated sequence
CCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACA| |TGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTC
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
35836198/35836096 (Hg38)
End
35836198/35836096 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
LOC105374724
Nearest miRNA
hsa-mir-10397/Upstream/3441621; hsa-mir-103a-1/Downstream/311796;
Nearest TSS
ENST00000502646/Upstream/9078; ENST00000515665/Downstream/16599;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/217859, chr5-CpG: 85/Downstream/315299
Nearby gene
SPEF2(-21485) ; IL7R(+20779) ;
Upstream sequence
caaaccatacctaagccattgtaggacctaaacaatatctttttcaatgaaAAGAAGGACATCAGTCCTTTCTCTTTCCCATCACTCTTCTACACATCTA
Downstream sequence
TCCGACATTCTTTTTTATTATCTTGACTAAATTTTTAAAATTTAAGTATGCCAAGTGATGAAATTTAAAATTTCTGAATAATTTTAACTTTAAATATCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate