Basic Information
VIS ID
TVIS10008569
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1700
Orient
-
Integrated sequence
GCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTG| |AGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT
Host Sequence
Chromosome
chr5
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
68339062/69043235 (Hg38)
End
68339062/69043235 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/9339532; hsa-mir-103a-1/Downstream/3126232;
Nearest TSS
ENST00000502646/Upstream/13070; ENST00000502979/Downstream/586;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/754612, chr5-CpG: 62/Downstream/50615
Nearby gene
PIK3R1(-741413) ; SLC30A5(+50714) ;
Nearest cancer related gene
PIK3R1(OG, -741413) ;
Upstream sequence
TGCCGGACGTGAAGGGGAGGACGGAGGCGCGTAGACGCGGCTGGGGACGAACCCGAGGACGCATTGCTCCCTGGACGGGCACGCGGGACCTCCCGGAGTG
Downstream sequence
AAGTTGTGGCACTTCAATGTATTTGTCGTTCTCGGACAGCAAAGTAAGTCAAACGCGAAACAACTCCCCCTTCACATCCCGGATGCCCTGCCTCCATTGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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