Basic Information
VIS ID
TVIS10008573
Fusion event
HBV-KMT2C integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1932
Orient
+
Integrated sequence
CTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA| |GCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGT
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152011389/152314304 (Hg38)
End
152011389/152314304 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/880665; hsa-mir-153-2/Downstream/5260032;
Nearest TSS
ENST00000635602/Upstream/2008; ENST00000564834/Downstream/121495;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/182747, chr7-CpG: 31/Downstream/52445
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
aaacaaccaatcaaaatttatcatgaacacatatgtgaaatttttaagtaaaattgcaacaaatgaatccagcaatatattaaagaaagacaatatataa
Downstream sequence
TTACATCATAACCCTCAAGAGGCAGTGTTAGCTTTGCAAGCTAAATTAATTTTTACACATTCTCATCAACTACAGAAACTTCTACTCCCTTAACCAGCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate