VISDB Viral Integration Site DataBase

VIS ID

TVIS10008574

Fusion event

HBV-MTSS1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1820

Orient

-

Integrated sequence

TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT

Chromosome

chr8

Cytoband

q24.13

Reference genome

Start

End

125727090/124714849 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA8C ; FRA8E

Target gene

miRNAs that regulate target gene

hsa-mir-182-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-135a-5p ; hsa-mir-7111-3p ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193 ; hsa-mir-33a-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-96-5p ; hsa-mir-15b-5p

Nearest miRNA

hsa-mir-12123/Upstream/206273; hsa-mir-10400/Downstream/107129;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/175569, chr8-CpG: 161/Downstream/12595

Nearest cancer related gene

MTSS1(TSG, No orient, 0)

Upstream sequence

CAACTACAGATGTATAATTTTTCTTAATGCCTTTTAGTAACCTAGTTTATCCCCAAACAAATAGATTCATGCCACATAAAACTGAGACTTTTGATGTCTT

Downstream sequence

AATATTTAACCACCTAATACAGGGGCTGGCTGCTTTTACCTAGCATTTGTATAAGCTTAATCCTCCCCAGAATAATACATATCTACCCTCTAACCTTTGT