Basic Information
VIS ID
TVIS10008576
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
163
Orient
+
Integrated sequence
GGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGA| |ACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTG
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
50373291/49460732 (Hg38)
End
50373291/49460732 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/6564457; hsa-mir-10400/Downstream/12254056;
Nearest TSS
ENST00000518652/Upstream/292050; ENST00000521574/Downstream/51448;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/482417, chr8-CpG: 49/Downstream/448978
Nearby gene
PPDPFL(-384649) ; SNTG1(+451306) ;
Upstream sequence
TGTTTATTGCCTATCTGTATGTCTCTACAGAACAACCCTGCGCTTATACTTAGTGATGATAAGAATGCATTTGTTTTTTGTGCTTAATACAGCTTTAcag
Downstream sequence
ATTGGTTTTATTTTCTTCTTCTTATATTGGGCATTTAGTTCCTCTTGATCTATGGAAGGGTTTTTGGTATGGTTTTGTTTGATTTTTAGGCAGTCTTACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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