Basic Information
VIS ID
TVIS10008577
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
543
Orient
+
Integrated sequence
TCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAA| |GGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTAT
Host Sequence
Chromosome
chrX
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
133156945/134022918 (Hg38)
End
133156945/134022918 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/12651865; hsa-mir-105-1/Downstream/146460;
Nearest TSS
ENST00000429181/Upstream/37023; ENST00000370809/Downstream/214129;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/37420, chrX-CpG: 111/Downstream/148730
Nearby gene
GPC3(-37272) ; MIR363(+146463) ;
Nearest cancer related gene
GPC3(TSG, -37272) ;
Upstream sequence
GTAATACATTCCTGTGAAATAGAAATTCCAGAGCCATCATGGCTGACAGAGTTTATACGTTTGAGATACGAGAATGCCCACTGATATTTTATCAGCCAAT
Downstream sequence
aaaattaaactctttaacatgattttcaaggcccttcataatcagatcTTGCTTTGacagtgctgtgtaatgattagacttgagcaagactggctgggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate