Basic Information
VIS ID
TVIS10008588
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2511
Orient
+
Integrated sequence
GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
117838931/117968216 (Hg38)
End
117838931/117968216 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11B
Nearest miRNA
hsa-mir-10392/Upstream/4518128; hsa-let-7a-2/Downstream/675784;
Nearest TSS
ENST00000527297/Upstream/38757; ENST00000531365/Downstream/18132;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/91378, chr11-CpG: 62/Downstream/17707
Nearby gene
TMPRSS13(-38763) ; IL10RA(+18175) ;
Upstream sequence
ggagtctcgctctgtcgcccagtctggagagcagtagcatgatcttggctcactgcaacctctgcctcccagattcaagctattctgctgcctcagcctc
Downstream sequence
ctgagtagctgggattacaggcgcccacaaccacacccagctaatttttgtatttttcagtagagacggggtttcgccatgtcggccaggctggcctcga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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