Basic Information
VIS ID
TVIS10008590
Fusion event
HBV-LOC105370251 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1349
Orient
+
Integrated sequence
TTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTC| |CTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATC
Host Sequence
Chromosome
chr13
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
68377562/67803430 (Hg38)
End
68377562/67803430 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
LOC105370251
Nearest miRNA
hsa-mir-1297/Upstream/1585106; hsa-mir-1267/Downstream/9894582;
Nearest TSS
ENST00000623511/Upstream/431043; ENST00000627910/Downstream/1074950;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/572103, chr13-CpG: 34/Downstream/1181342
Nearby gene
PCDH9(-573094) ; LINC00550(+1057855) ;
Upstream sequence
ATTCAGCCGACTAAAGAATTCAGTGTTTGCTCTCAGCAATTATTATGACGGATGGCTGCAGCACGCCATTGTTTTGTCTGCCTCGGAGGTGGTCGTGGCA
Downstream sequence
AGACTGTCTCTGCTCCGGAGGGGTGTTTAGCTACATGTTTACAAAAGTGGCTAAGGCCTTAGGGATTAGATTTATCTCACAGTTAAAGGCAGCTTTTTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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