VISDB Viral Integration Site DataBase

VIS ID

TVIS10008596

Fusion event

HBV-AKAP13 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2511

Orient

+

Integrated sequence

GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT

Chromosome

chr15

Cytoband

q25.3

Reference genome

Start

End

86173133/85629902 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-423-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-16-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-8074 ; hsa-mir-6778-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1281 ; hsa-mir-3667-3p ; hsa-mir-6832-3p ; hsa-mir-183-5p

Nearest miRNA

hsa-mir-10393/Upstream/249240; hsa-mir-11181/Downstream/140594;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/248453, chr15-CpG: 20/Downstream/128816

Nearest cancer related gene

AKAP13(OG, No orient, 0)

Upstream sequence

agtgtctggctgtgtcacccaggctggagtgcagcagtgctgtcttggctcactgaaacctccacctcccgggctcaagccagcctcccacctcagcctc

Downstream sequence

ctgagtagctgggattacaggcgcccacaaccatgtccagctaatttttgtattttttgtggagacagggtttttccatgttgcccaggctggtcttgaa