Basic Information
VIS ID
TVIS10008597
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
12388503/12485186 (Hg38)
End
12388503/12485186 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/403190; hsa-mir-10226/Downstream/432082;
Nearest TSS
ENST00000595228/Upstream/283586; ENST00000577679/Downstream/64596;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/463632, chr17-CpG: 70/Downstream/180164
Nearby gene
MAP2K4(-341452) ; LINC00670(+64782) ;
Nearest cancer related gene
MAP2K4(TSG, -341452) ;
Upstream sequence
GAAAGACTGAAATGGTTAACTACATACAGTTAGACTTCTTATTTCATAACTTATGAACTGACCACTGTTTCTCACTTCCAATGCCTTAATCCACAGCAGA
Downstream sequence
AAGTCTGCTGGGAGTCCAGGCCTCCCCACCCACCCCTTCCCTTGCCACACCATTGTAAATGGCTCCCTCTAAGCCAAGAGAATGTGCTTCTTGGCATAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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