Basic Information
VIS ID
TVIS10008609
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2511
Orient
+
Integrated sequence
GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT
Host Sequence
Chromosome
chr20
Cytoband
p13
Reference genome
GRCh37/hg19
Start
1182406/1201762 (Hg38)
End
1182406/1201762 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-1/Downstream/191138;
Nearest TSS
ENST00000382410/Upstream/16347; ENST00000400633/Downstream/1692;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/15804, chr20-CpG: 103/Downstream/23704
Nearby gene
TMEM74B(-17289) ; C20orf202(+1692) ;
Upstream sequence
AGTGCATGTGAATAGaataaatttatatatatacatttgcagtctcagttcactgcaacctccgcctcctgggttcaagaaattctcctgctccagcctc
Downstream sequence
ctgagtagctgggattacaggcgcccacaaccacacccggctaatttttgtatttttagtagagacggggtttcaccatgtttagccaggctggtctcga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate