Basic Information
VIS ID
TVIS10008610
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2511
Orient
+
Integrated sequence
GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
21668275/20295963 (Hg38)
End
21668275/20295963 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/1609799; hsa-mir-155/Downstream/2783321;
Nearest TSS
ENST00000624081/Upstream/37143; ENST00000486367/Downstream/507100;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2050406, chr21-CpG: 89/Downstream/701142
Nearby gene
TMPRSS15(-1892305) ; LINC00320(+446638) ;
Upstream sequence
gagaccagcctggccaacatagtgaaactctgtctctactaaaaatacaaaagatcagctgggcgtggttgtgggcgcctgtaatcccagctactcagga
Downstream sequence
ggctgaggcaggagtatcgcttgatcctgggaggtggaggtttcactgagctgagatcatgccattgtcttccagcctaggaaaaaaagagcaatattct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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