Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008613
Fusion event
HBV-MICAL3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|
Start
2959
Orient
+
Integrated sequence
ATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAA| |CAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCT
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
Start
End
18505610/18022844 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-3198-1/Upstream/41883; hsa-let-7a-3/Downstream/1940909;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/21110, chr22-CpG: 91/Downstream/809
Upstream sequence
AAGTGTCCATTCTCCTTGTAGTGAGTGGGTGGTGGGGGGATATACACATGTGACTCTGGTTAGTACATAGGCAGCCATGAAGTCCACAAATGTACAGGGA
Downstream sequence
GCCACAGCTTTCATGCTACAGACTTGCAAAGGTATGCATCTGCTTTCCCCTTGCCCTGGAATATAGATCAGAACACTTCATTTAGTGAAGGGACCTGTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.