VISDB Viral Integration Site DataBase

VIS ID

TVIS10008621

Fusion event

HBV-TERT integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2630

Orient

+

Integrated sequence

AAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGC| |AATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTA

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1286871/1286756 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/223782; hsa-mir-10397/Downstream/22554;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/516, chr5-CpG: 485/Downstream/2404

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

tgaaatcccgtctctcctaaaaatacaaaaattagctgggcgtggtagcacgtgcctgtaatcccagctactcgagaggctgaggcaggagaatcgctgg

Downstream sequence

aatcccagctactcatgaggttgaggaatgagaactgcttgaaccgaggaggcagaggttgcagtgagccgagattgtgccattacactccagcctgggt