Basic Information
VIS ID
TVIS10008626
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
134767201/135431511 (Hg38)
End
134767201/135431511 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5C
Nearest miRNA
hsa-mir-10397/Upstream/1205659; hsa-mir-103a-1/Downstream/371474;
Nearest TSS
ENST00000502646/Upstream/31597; ENST00000510230/Downstream/15837;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/31940, chr5-CpG: 22/Downstream/57302
Nearby gene
H2AFY(-31624) ; DCANP1(+12703) ;
Upstream sequence
tctggccccagccatctctccagcctcatttctgGTGACTCCCAGATCTGGCCCCAGCCATGTCTCTAGACTCCAAACTTATTCCTTATAATGCTCCCAC
Downstream sequence
cccagctacgcgggagggtgaggcaggagaatcacttgaacctgggaggcagaagttgcagtgagcctagatcgtgccactccactccagcctgagcaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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