Basic Information
VIS ID
TVIS10008629
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2511
Orient
+
Integrated sequence
GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
37009269/37041493 (Hg38)
End
37009269/37041493 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/418981; hsa-mir-10398/Downstream/513872;
Nearest TSS
ENST00000381078/Upstream/19951; ENST00000468243/Downstream/128710;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/54799, chr6-CpG: 23/Downstream/3340
Nearby gene
FGD2(-12424) ; PIM1(+128653) ;
Nearest cancer related gene
PIM1(OG, +128653) ;
Upstream sequence
cccacacattaataatgggagactttaataccccactgtcaacattagacagatcagtgagacagaaagttaacaaggatacccaggaattgaactcagc
Downstream sequence
ggctgaggcaggagaatcacttgaacccaggaagtggaggttgcagtgagctgagatcgtgccactgcactccagcctgggcaacaagagtgaaactctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate