Basic Information
VIS ID
TVIS10008631
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2511
Orient
+
Integrated sequence
GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
101397113/101753833 (Hg38)
End
101397113/101753833 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7F
Nearest miRNA
hsa-mir-10525/Upstream/594278; hsa-mir-10399/Downstream/539270;
Nearest TSS
ENST00000635602/Upstream/124537; ENST00000607092/Downstream/62071;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/9991, chr7-CpG: 392/Downstream/60305
Nearby gene
MYL10(-124537) ; CUX1(+62071) ;
Nearest cancer related gene
CUX1(TSG, +62071) ;
Upstream sequence
ggtctttctttttcagtttgttactatggtgaattcacctgattggttttcaaatagtgagacaactttgcattcctgggataaactccacttgcacatt
Downstream sequence
gctgaggaaggagaatggcttgaatccgggaggtggaggttgcagtgagccaagatcatgtcactacactacagcgtaggggatagagcgagactccatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate