VISDB Viral Integration Site DataBase

VIS ID

TVIS10008632

Fusion event

HBV-METTL2B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2511

Orient

+

Integrated sequence

GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT

Chromosome

chr7

Cytoband

q32.1

Reference genome

Start

End

128143948/128503894 (Hg38)

Orient

+

Location type

downstream

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-484 ; hsa-mir-92a-3p ; hsa-mir-6879-3p ; hsa-mir-593-5p ; hsa-mir-767-5p ; hsa-mir-3655 ; hsa-mir-6741-3p ; hsa-mir-500b-3p ; hsa-mir-183-5p ; hsa-mir-5197-5p ; hsa-mir-3145-5p ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-508-5p ; hsa-mir-5186 ; hsa-mir-6499-3p ; hsa-mir-6512-3p ; hsa-mir-6516-5p ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-766-3p ; hsa-mir-1200 ; hsa-mir-1281 ; hsa-mir-1297 ; hsa-mir-1915-3p ; hsa-mir-193b-5p ; hsa-mir-1976 ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-3170 ; hsa-mir-3614-3p ; hsa-mir-3653-5p ; hsa-mir-3691-3p ; hsa-mir-4279 ; hsa-mir-4297 ; hsa-mir-4324 ; hsa-mir-4438 ; hsa-mir-4465 ; hsa-mir-4485-5p ; hsa-mir-4722-3p ; hsa-mir-4726-3p ; hsa-mir-4777-3p ; hsa-mir-498 ; hsa-mir-5089-5p ; hsa-mir-5095 ; hsa-mir-5571-5p ; hsa-mir-5581-5p ; hsa-mir-5697 ; hsa-mir-6504-3p ; hsa-mir-6506-5p ; hsa-mir-6513-3p ; hsa-mir-660-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6764-5p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6840-3p ; hsa-mir-6855-5p ; hsa-mir-6869-5p ; hsa-mir-6872-3p ; hsa-mir-6890-5p ; hsa-mir-7151-3p ; hsa-mir-8062 ; hsa-mir-122-5p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4423-5p ; hsa-mir-4430 ; hsa-mir-4639-3p ; hsa-mir-504-3p ; hsa-mir-6501-5p ; hsa-mir-6794-3p ; hsa-mir-744-3p

Nearest miRNA

hsa-mir-10525/Upstream/295951; hsa-mir-10399/Downstream/1266489;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/26636, chr7-CpG: 189/Downstream/26626

Upstream sequence

tttcagtttgttactatggtgaattcacctgattggttttcaaatagtgagacaactttgcattcctgggataaactccacttgcacattatatattgtc

Downstream sequence

ggctgaggtaggagaattgcttgaacctgggaggcggaggttgcagtgagctgagatggtgccattgcactccagcctgggcgacaagagcgaaactgca