Basic Information
VIS ID
TVIS10008633
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2511
Orient
+
Integrated sequence
GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
77306365/77677048 (Hg38)
End
77306365/77677048 (Hg38)
Orient
-
Location type
Intronic
Target gene
APTR ; LOC105375363
Nearest miRNA
hsa-mir-10525/Upstream/1761779; hsa-mir-10399/Downstream/14526967;
Nearest TSS
ENST00000635602/Upstream/40076; ENST00000462800/Downstream/19205;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/139028, chr7-CpG: 104/Downstream/19045
Nearby gene
PTPN12(-36977) ; APTR(+6803) ;
Upstream sequence
CACATTTCTTGTGATATAACTGATCAGGACACACCCATTTGTTGTTACATCAGAGTTGATCATTAATGGAGCAGATATTTTCAAAAGAGGCTTTCAGCGT
Downstream sequence
ctgagtagctgggattacaggcgcccacaaccatacccagctgatctttgtatttttagtagagacaggggtttaccatgtcatgttggccaggctggtc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate