VISDB Viral Integration Site DataBase

VIS ID

TVIS10008638

Fusion event

HBV-ELF4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2511

Orient

+

Integrated sequence

GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT

Chromosome

chrX

Cytoband

q26.1

Reference genome

Start

End

129225299/130091324 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-877-5p ; hsa-mir-615-3p ; hsa-mir-505-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-let-7f-5p ; hsa-mir-331-5p ; hsa-mir-4666a-5p ; hsa-mir-8068 ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-5087 ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-298 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-4678 ; hsa-mir-376c-3p

Nearest miRNA

hsa-let-7f-2/Upstream/8720271; hsa-mir-105-1/Downstream/4078054;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/30596, chrX-CpG: 189/Downstream/18375

Nearest cancer related gene

ELF4(OG, No orient, 0)

Upstream sequence

tcacatctaacagaacttgctaaagactcagggatttttaaaaagggaagggtagcagagaataaaaaaactataatacttcaaactgaatatcaggtac

Downstream sequence

ggctgaggcaggagaatcgcttgaacccgggaggcagaggtgcagtgagccgacatcgtgccactgcactccagcctgggcaacaagagtgaaactccat