Basic Information
VIS ID
TVIS10008639
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1587
Orient
-
Integrated sequence
CGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACT| |TCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCA
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
69439474/70219624 (Hg38)
End
69439474/70219624 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/196701; hsa-mir-105-1/Downstream/3998753;
Nearest TSS
ENST00000429181/Upstream/42141; ENST00000480702/Downstream/15031;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/85570, chrX-CpG: 34/Downstream/70170
Nearby gene
DGAT2L6(-13921) ; AWAT1(+15031) ;
Upstream sequence
cgctgtttagcccaggccggattgcagtggcgcaatctcggctcactgcaagctccgcctcccaggttcacgccattctcctgcctcagcctcccgagta
Downstream sequence
TGCTACAGGGGAAGTAAGCTATTATTTGGAGGAAAGAGTTAAAATGTCATGCCGTATACCTAAGTGTATTGTAATTAGATTAAAGAGTTTCATTTAAATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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