Basic Information
VIS ID
TVIS10008658
Fusion event
HBV-LINC01780 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1829
Orient
-
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr1
Cytoband
p12
Reference genome
GRCh37/hg19
Start
119881864/119339241 (Hg38)
End
119881864/119339241 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01780
Nearest miRNA
hsa-mir-101-1/Upstream/2244513; hsa-mir-1182/Downstream/26511346;
Nearest TSS
ENST00000473358/Upstream/10989; ENST00000457318/Downstream/29538;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/11329, chr1-CpG: 134/Downstream/283438
Nearby gene
WARS2(-198569) ; HAO2(+29538) ;
Upstream sequence
ACACATTATTCATCTGTGCCCTGAATAGCTGCCCATAATCCAGATACTGCAGAAACAGGGAGCAGGAACACCAAATTCCTTGACTTCAGAAGGCATTATC
Downstream sequence
CAGAAATAAGACAGAAAACATCTGAATAGAGCTATGAGCCAGCAGCATTCATTTTTTCCTGCCCTCCCTTCATCTGCATCCTCCTCCGCTACCAAGCCCa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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