Basic Information
VIS ID
TVIS10008660
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1742
Orient
-
Integrated sequence
CCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGT| |TGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATC
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
145080458/148803903 (Hg38)
End
145080458/148803903 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1F
Nearest miRNA
hsa-mir-101-1/Upstream/415540; hsa-mir-1182/Downstream/1688442;
Nearest TSS
ENST00000473358/Upstream/55009; ENST00000610852/Downstream/4278;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/54854, chr1-CpG: 41/Downstream/4618
Nearby gene
PDE4DIP(-4272) ; SEC22B(+15949) ;
Upstream sequence
tggctcacgcctgtattcccagcactttgggagactgaggcaggcggatcatgagctcaggagttcgagaccagcctgaccaacatggtgaaatccccgt
Downstream sequence
ctctactaaaaatacaaaaattagctgggcgtggtggcatgcacctgtaatcccagctactcaggaagctgaagcaggataattgcttaaatctgggagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate