Basic Information
VIS ID
TVIS10008664
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1797
Orient
-
Integrated sequence
TTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATT| |GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
151456709/151484233 (Hg38)
End
151456709/151484233 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1F
Nearest miRNA
hsa-mir-101-1/Upstream/932219; hsa-mir-1182/Downstream/61563;
Nearest TSS
ENST00000473358/Upstream/24768; ENST00000505188/Downstream/26277;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10567, chr1-CpG: 57/Downstream/26864
Nearby gene
POGZ(-24768) ; CGN(+27153) ;
Upstream sequence
cattggcatcccatgccctagtcttgcagacctcctcaccacccccttagcactccatgcactgccatgcttccttgctttggacttgTGAGTCCTCACT
Downstream sequence
GGATTTATTCCCACTAGTCTTTTAGCTCTCCATTTAATGTTTCTTCATTTGTGAAAGCTTTCTTGATTCTCCTTTGTTTGGTGAAGCACCCCTTCCTCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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