Basic Information
VIS ID
TVIS10008665
Fusion event
HBV-MROH9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1759
Orient
-
Integrated sequence
GAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGG| |TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC
Host Sequence
Chromosome
chr1
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
170957404/170988263 (Hg38)
End
170957404/170988263 (Hg38)
Orient
-
Location type
Intronic
Target gene
MROH9
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/836801; hsa-mir-1182/Downstream/113465;
Nearest TSS
ENST00000473358/Upstream/52737; ENST00000426136/Downstream/4054;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/323226, chr1-CpG: 56/Downstream/497115
Upstream sequence
gagccctgtgcaaacacataggtcacaggcccatgaaaccagtcctgATGGTGACATGAGGAATGAACCTCCAGTTCCCTCTCCTGACACAGGAGTGCAA
Downstream sequence
GGTGACTGAAAATAATCTGAGAAGTCTTACTCAAATTCATAGAGCAGGAAAGGGGAGGAGATGCTTTATATAGAACTCTCAATGCTGCTGCAGATGGGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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