Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008670
Fusion event
HBV-CFH integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2325
Orient
+
Integrated sequence
CACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCA| |ACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAA
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
End
196683167/196714037 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-101-1/Upstream/131556; hsa-mir-1182/Downstream/2144836;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/105156, chr1-CpG: 29/Downstream/163991
Upstream sequence
GTATTGATTATCCAGATGATACACAAAAGTTTACTAACTTTAGTCTTTTTGTGGGGGCTGATATAATTTCATTTGAAAAGATAAGAAAAAAAAACCTGCA
Downstream sequence
GGAACAAAGCAGACATCAATTTTTTTTCCTTTTCACATTAATTACTCAGATATTAGTCTGTCTTTCCATTCAGGCTTTTCCTACTCTAAAGCATTCTGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.