Basic Information
VIS ID
TVIS10008671
Fusion event
HBV-MIR181A1HG integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2277
Orient
+
Integrated sequence
TATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGG| |ATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAA
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
198886664/198917535 (Hg38)
End
198886664/198917535 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR181A1HG
Nearest miRNA
hsa-mir-101-1/Upstream/58382; hsa-mir-1182/Downstream/2801973;
Nearest TSS
ENST00000473358/Upstream/90319; ENST00000422480/Downstream/19875;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/758301, chr1-CpG: 36/Downstream/1117811
Upstream sequence
TTCACCCCATAGAAAGAATAAAACCCCTGACGTTTATGTGGCCAGTTTCTAGGAAGTATAATTCTGTCATCTGGCCAAAATAcagacataccatatttta
Downstream sequence
ttacacttcactttattgcactttgcagaaattgtgctttttgcaaataaaatgcttgtagcaaccctgcattgagcaagtctgtctgtgccatttttcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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