Basic Information
VIS ID
TVIS10008673
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1032
Orient
+
Integrated sequence
AAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTA| |CACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACA
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
211698798/211525456 (Hg38)
End
211698798/211525456 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1901946; hsa-mir-1182/Downstream/552157;
Nearest TSS
ENST00000473358/Upstream/32539; ENST00000430123/Downstream/53286;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/9694, chr1-CpG: 180/Downstream/52323
Nearby gene
RD3(-32539) ; SLC30A1(+49583) ;
Upstream sequence
gcctgctgggctgcattcccaggaggttaggcattcttagtcacaggatgagataggaggacaatacaagatacaggtcacaaagaccccactgataaaa
Downstream sequence
caggatgcggtaacaaagctggccaaaacccatgaaaaccaagatggcagtgaaagtgacctttggtcattctcactgctcctaacatgctaattacgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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