Basic Information
VIS ID
TVIS10008674
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1776
Orient
-
Integrated sequence
CAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACT| |AGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCA
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
211698801/211525459 (Hg38)
End
211698801/211525459 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1901949; hsa-mir-1182/Downstream/552154;
Nearest TSS
ENST00000473358/Upstream/32542; ENST00000430123/Downstream/53283;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/9697, chr1-CpG: 180/Downstream/52320
Nearby gene
RD3(-32542) ; SLC30A1(+49580) ;
Upstream sequence
tgctgggctgcattcccaggaggttaggcattcttagtcacaggatgagataggaggacaatacaagatacaggtcacaaagaccccactgataaaacag
Downstream sequence
gatgcggtaacaaagctggccaaaacccatgaaaaccaagatggcagtgaaagtgacctttggtcattctcactgctcctaacatgctaattacgatgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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