Basic Information
VIS ID
TVIS10008675
Fusion event
HBV-LYPLAL1-DT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1151
Orient
+
Integrated sequence
GTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCC| |GTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTT
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
219315301/219141959 (Hg38)
End
219315301/219141959 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LYPLAL1-DT
Nearest miRNA
hsa-mir-101-1/Upstream/7064274; hsa-mir-1182/Downstream/975894;
Nearest TSS
ENST00000473358/Upstream/225775; ENST00000496776/Downstream/31885;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/794795, chr1-CpG: 46/Downstream/31808
Upstream sequence
GCCTGGGGTCACAAATGAATTCTATGGAGCTGTGACAACAGACTCAGGACCAGCGTGGATAATGCCATGGAGTCCCTGCCTCCCCTGTGATTACCCATTC
Downstream sequence
CTTCAGTTCTCAAAGGCTGTGGAAGCATCTGAAGAACAAAAAGCACAGGTGTAAATTGCTGAATACCATTCAGGTGGCTAAAAAAAGCCATCACTGGTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate