Basic Information
VIS ID
TVIS10008676
Fusion event
HBV-LYPLAL1-DT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2263
Orient
-
Integrated sequence
TATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGT| |CTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAG
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
219315304/219141962 (Hg38)
End
219315304/219141962 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
LYPLAL1-DT
Nearest miRNA
hsa-mir-101-1/Upstream/7064277; hsa-mir-1182/Downstream/975891;
Nearest TSS
ENST00000473358/Upstream/225778; ENST00000496776/Downstream/31882;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/794798, chr1-CpG: 46/Downstream/31805
Upstream sequence
TGGGGTCACAAATGAATTCTATGGAGCTGTGACAACAGACTCAGGACCAGCGTGGATAATGCCATGGAGTCCCTGCCTCCCCTGTGATTACCCATTCCTT
Downstream sequence
CAGTTCTCAAAGGCTGTGGAAGCATCTGAAGAACAAAAAGCACAGGTGTAAATTGCTGAATACCATTCAGGTGGCTAAAAAAAGCCATCACTGGTTGATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate