NFYC _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008681
Fusion event
HBV-NFYC integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1994
Orient
+
Integrated sequence
TTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCT| |AGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAA
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
GRCh37/hg19
Start
41235656/40769984 (Hg38)
End
41235656/40769984 (Hg38)
Orient
+
Location type
Intronic
Target gene
NFYC
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-155-5p ; hsa-mir-221-3p
Nearest miRNA
hsa-mir-12136/Upstream/12612; hsa-mir-101-1/Downstream/2401668;
Nearest TSS
ENST00000473358/Upstream/1254; ENST00000509682/Downstream/13830;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/77681, chr1-CpG: 128/Downstream/13434
Upstream sequence
AATCTTCCCTTTTCCCTCTGCTTTCCCCTCACAGTACAGTCCCAGAGACCACTGAGGACATGATAGGATGACATGCCCAAACTTGTGCCCTCTGCTGCTC
Downstream sequence
AAAAGGGAGAAGAGCTGGCATCAGGACCCACCTCTGGCTTCTGCCAGCACCACATGCTAGGCTTACATGCCAGGGCTCCCATGAGGGCTTGGCTTTTGGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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