Basic Information
VIS ID
TVIS10008682
Fusion event
HBV-LOC105378711 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
50672109/50206437 (Hg38)
End
50672109/50206437 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105378711
Nearest miRNA
hsa-mir-12136/Upstream/5660885; hsa-mir-101-1/Downstream/853400;
Nearest TSS
ENST00000473358/Upstream/29307; ENST00000642132/Downstream/16690;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/157789, chr1-CpG: 86/Downstream/126558
Nearby gene
ELAVL4(-4569) ; DMRTA2(+211114) ;
Upstream sequence
CATTTTATTTCCATGAGCTGAAATCAAGTTTTAATATTGTCCAGAAATGACTCGTACCATTCCCTTATCTTATTAGCTTTTTGGCGTATTAGGTAATAAG
Downstream sequence
ATAATTTCTCATGGTACAGTATTTATGTAAGAATCATATTTCTCTCTGTGCAGATCACTTACAGAAGTGTCTGTTAACAGGAGAGAATGATACATAATCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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