Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008688
Fusion event
HBV-LEPR integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
632
Orient
+
Integrated sequence
CTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGG| |AAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTT
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
Start
End
66072334/65606651 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-101-1/Upstream/548143; hsa-mir-11399/Downstream/1021789;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/80523, chr1-CpG: 63/Downstream/186106
Upstream sequence
aaatgtagacagctcctcataccttcccagcatgggtattgagggaatcacgtaaactattgaacttcaagcATATCCTTTCTGCAGACTGGATATTCAC
Downstream sequence
TGCCAGTCTGCAGAAAGGATATGATTCATATGATTCAGTTAATTGCAAACACAGATTTAACCTCTTACAGTCTCTTGAATATTGATACTTCCTTTCCTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.