Basic Information
VIS ID
TVIS10008690
Fusion event
HBV-LOC107984913 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr1
Cytoband
p36.31
Reference genome
GRCh37/hg19
Start
6665942/6605882 (Hg38)
End
6665942/6605882 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC107984913
Nearest miRNA
hsa-mir-12136/Upstream/175986; hsa-mir-101-1/Downstream/2260620;
Nearest TSS
ENST00000473358/Upstream/2198; ENST00000495385/Downstream/7803;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2098, chr1-CpG: 310/Downstream/6844
Nearby gene
KLHL21(-3013) ; PHF13(+7814) ;
Upstream sequence
CTTAATTTTGGTATTTAAATTCTAATTTAAGGCAGACAGAGCAAGAGGTGACTAAAATTACGTTACCttttttttcttgagacagagtctcgctgtgtca
Downstream sequence
cccaggctgcagtgcagtggcgcgatctcggctcaccgcaacctctgcctcccgggttaaagcaattctcctgcctcagccttcctgagtggctgggatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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