VISDB Viral Integration Site DataBase

VIS ID

TVIS10008696

Fusion event

HBV-ZMYND11 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2331

Orient

+

Integrated sequence

TGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTT| |CCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTC

Chromosome

chr10

Cytoband

p15.3

Reference genome

Start

End

228683/182743 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-361-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-324-5p ; hsa-mir-125b-5p ; hsa-mir-27b-3p ; hsa-mir-222-3p ; hsa-mir-10b-5p ; hsa-mir-548q ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-6828-5p ; hsa-mir-138-5p ; hsa-mir-1468-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-548aj-5p ; hsa-mir-4484 ; hsa-mir-548an ; hsa-mir-4698 ; hsa-mir-548aw ; hsa-mir-6768-3p

Nearest miRNA

hsa-mir-107/Downstream/458946;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/46231, chr10-CpG: 32/Downstream/117821

Nearest cancer related gene

ZMYND11(TSG, No orient, 0)

Upstream sequence

CATAACATTAATCACATTTGTCATTGTTTCCCTGCTAGACAGCTCCAAGAAAGAACTGTCTAGAAAATTGCCTAACCCGGCCAGTGCCTTTGCTTCTTGG

Downstream sequence

CTAATATTAATTTCCTTGTTTATTAAacttgcctaaggtaagttaggaagtagcattgcattatggcaggaagtcagatcttttgctctaaagcctaata