Basic Information
VIS ID
TVIS10008699
Fusion event
HBV-LINC00836 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2901
Orient
+
Integrated sequence
GCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACC| |AGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGC
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
25960550/25671621 (Hg38)
End
25960550/25671621 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC00836
Nearest miRNA
hsa-mir-1265/Upstream/1395840; hsa-mir-107/Downstream/2617637;
Nearest TSS
ENST00000439456/Upstream/19846; ENST00000376301/Downstream/262089;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/494911, chr10-CpG: 96/Downstream/262371
Nearby gene
GPR158(-69393) ; MYO3A(+262452) ;
Upstream sequence
atctacctatctacctacctacctaAtttcacaaaagatttgaggcaatattacacaatattcatagttatatacattaaaaaaatcagagttagggaaa
Downstream sequence
ctaTCAACAGAGAGAAAGATAGGGTCAGGTTAATGATTGGGACAAGGACAGCctcatgccaataattccaacaccttgggaggctgaagtgggaggatag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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