SVIL _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008700
Fusion event
HBV-SVIL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1987
Orient
+
Integrated sequence
GGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAG| |ATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTG
Host Sequence
Chromosome
chr10
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
29842029/29553100 (Hg38)
End
29842029/29553100 (Hg38)
Orient
+
Location type
Intronic
Target gene
SVIL
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1265/Upstream/8003; hsa-mir-107/Downstream/49164;
Nearest TSS
ENST00000439456/Upstream/30532; ENST00000375322/Downstream/81872;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/142985, chr10-CpG: 234/Downstream/182043
Upstream sequence
agaggtggagtctggccgtgttgtccaggctaatcttgcactcctgagctccagctattctcctgcctcagcctcccaaagtgctggaattactggtgtt
Downstream sequence
gagccaccaagcccagccTTTTTTTTTTTTTTTTCAATAATTGCATGTGATTTTAAAATATCTTAGTTTTCTAGCTTTCTGGCCACAGGAAATTGGAAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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