Basic Information
VIS ID
TVIS10008710
Fusion event
HBV-SHLD2P1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
+
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
46922107/46627508 (Hg38)
End
46922107/46627508 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10G
Target gene
SHLD2P1
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-1265/Upstream/1463420; hsa-mir-107/Downstream/2358004;
Nearest TSS
ENST00000439456/Upstream/16387; ENST00000605984/Downstream/4879;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/47883, chr10-CpG: 38/Downstream/8092
Upstream sequence
TATTTGACTTATTAAGTCAATCCCAATAAATAAAATCCCAAACAACTGGTTGTCCGCTAAAATGTTAACTGCTTATTTAGGGTGTTGAGATTATGGCTGC
Downstream sequence
TATATGTTTATTTACTTGGCTTCTCTTAGCTTACTTTTCTAATCAGGTATTTTGTAATAAGACAAGAAAGCTATTTTAGTGATTGGTTTTAAGCAGTAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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