Basic Information
VIS ID
TVIS10008712
Fusion event
HBV-LOC107984026 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
535
Orient
+
Integrated sequence
TTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTA| |CTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAA
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
46974734/46574881 (Hg38)
End
46974734/46574881 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
LOC107984026
Nearest miRNA
hsa-mir-1265/Upstream/1410793; hsa-mir-107/Downstream/2410631;
Nearest TSS
ENST00000439456/Upstream/19351; ENST00000512997/Downstream/3336;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/17712, chr10-CpG: 127/Downstream/3178
Nearby gene
SYT15(-4133) ; GPRIN2(+18812) ;
Upstream sequence
TGGCTCTGCTTCCTGTTTTCAGACCTTGTTCTTCCCCGTGTCTGTGGAGCTGGGAAGCCTGGAAACAGCAGCAGACATGGGTTCTGTCTTTCATGGCCAA
Downstream sequence
GCGGAAGTTTTATTTCCATGGCAAAAGCACTTCCAAGGAGGGCTGCAGGAAGTCCAAGAGTTTAAAGACCTGCAAATGCCTGCAGGTGATTAATAATTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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