Basic Information
VIS ID
TVIS10008713
Fusion event
HBV-SHLD2P3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1766
Orient
-
Integrated sequence
CTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGG| |TCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTT
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
End
47404204/47714184 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-1265/Upstream/2550096; hsa-mir-107/Downstream/1271328;
Upstream sequence
AATAAAATCCCAAACAACTGGTTGTCCGCTAAAATGTTAACTGCTTATTTAGGGTGTTGAGATTATGGCTGCTATATGTTTATTTACTTGGCTTCTCTTA
Downstream sequence
GCTTACTTTTCTAATCAGGTATTTTGTAATAAGACAAGAAAGCTATTTTAGTGATTGGTTTTAAGCAGTAACTTGGAATATATGCTTTAGTTCTAGCTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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