VISDB Viral Integration Site DataBase

VIS ID

TVIS10008718

Fusion event

HBV-KAT6B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

85

Orient

+

Integrated sequence

AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAG| |TAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGG

Chromosome

chr10

Cytoband

q22.2

Reference genome

Start

End

76777341/75017583 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-590-3p ; hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-1236-3p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4795-5p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-6831-3p ; hsa-mir-4311 ; hsa-mir-129-5p

Nearest miRNA

hsa-mir-1265/Upstream/2296483; hsa-mir-107/Downstream/534875;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/190505, chr10-CpG: 37/Downstream/26199

Upstream sequence

ggcgcctgtaatcccagctactcaggaagctgaggaaggagaatcgcttgagcctgggaagcggaggttgcatcgagcccatatcgcaccattgcactcc

Downstream sequence

agcctaggcaacagagcaagtctctgtctcaaaaaaaaaaagtacaaagaaacaaaaGGTGGCAAGAAATTCGTTTTTTAAAACATCGCATGTTATGAGG