Basic Information
VIS ID
TVIS10008724
Fusion event
HBV-LOC105369477 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
-
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
107179518/107308792 (Hg38)
End
107179518/107308792 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369477
Nearest miRNA
hsa-mir-10392/Upstream/3458812; hsa-let-7a-2/Downstream/4038965;
Nearest TSS
ENST00000527297/Upstream/290268; ENST00000529675/Downstream/7479;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/289315, chr11-CpG: 20/Downstream/148923
Nearby gene
GUCY1A2(-290347) ; CWF19L2(+17554) ;
Upstream sequence
tttcaaagctcattttggaatactgagttacaatttttatctgtttgagggcatgtctgtgaaatcttattgtctgtagaaacatttggctcctattctc
Downstream sequence
tcttgtcatataataattttgtatgggatttaatTGTGATAATGTTCTGTAACGTATTCACTTAAATGAAGCAAGTTTGCTTCTACTTTTAAAGGGAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate