Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008726
Fusion event
HBV-FEZ1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|
Start
2964
Orient
+
Integrated sequence
TCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGG| |ACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGG
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
End
125322130/125452234 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-let-7a-2/Upstream/2070722; hsa-mir-3167/Downstream/1536224;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/285455, chr11-CpG: 100/Downstream/43007
Upstream sequence
AAAAAACAGCTCTGGTTATCACTGCAGAGTATTTTAATTTTACACTGTGCGGGAGGATGTGACGCAGTAATTTGGAGGGTATTTTGGCCCATGTAAACCT
Downstream sequence
GCTTTGAGGAGTCTCGGGCCTGCGGCACGGAGGTACAACGTACAGGCAGGAAGGGAGAAAAAGGAGCCACTGATCTGGCTGAGAACAAGAGGAACTCACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.