Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008729
Fusion event
HBV-CYP2R1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
682
Orient
-
Integrated sequence
TCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTAC| |TAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTT
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
Start
End
14900643/14879097 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-210/Upstream/2715330; hsa-let-7a-2/Downstream/1090436;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/233969, chr11-CpG: 68/Downstream/12257
Upstream sequence
GTTTTTAGAATTGGGATATTTAATTCTATAGAAGGATGCTTCAGATTAAGATGCTGTATCTAATGAATTATCATTATCCTTTATTCTAAAGTTACGCCCC
Downstream sequence
GTGAAAGTTCTCTTACCTAGGGAAAAAGGAACCAAAGCTTCCTTCTTGGCAAAATATCCACTGCTGTCCAGAAATCGCTCAGGATGGAACACTTCTGGGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.